Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq

Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15.

Functional gene description: The sensory systems reponsible for maintenance of equilibrium and balance are ontained within the vestibular portion of the inner ear. The toconial complex, an extracellular structure containing igh-density particles called otoconia, renders the receptor ells of the sensory macular epithelium responsive to gravity. he major matrix protein (otoconin-90, OC90) account...

A novel deletion in the Yq-chromosome of a patient with chronic myelomonocytic leukemia

At present the pathogenesis and therapeutic effect of chronic myelomonocytic leukemia (CMML) is still not very clear. There are no specific molecular biology characteristics in it. We report a novel deletion in the Yq chromosome of a patient with CMML, as well as the treatment and prognosis, and review the relevant literature, and put forward that the Y chromosome abnormality may be involved in...

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody

Mapping of a transcription promoter located inside the priA gene of the Bacillus subtilis chromosome.

The genome sequence of the Gram-positive soil bacterium Bacillus subtilis was completed in 1997 (Kunst et al., 1998) and the results included the identification of a putative transcription unit encompassing the yloI to yloS genes. Within this region of the B. subtilis chromosome 11 putative open reading frames were found with a wide diversity of probable functions. In this work we have analyzed...

Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1.

To identify the chromosomal location of a gene responsible for familial hypertrophic cardiomyopathy, we used clinical and molecular genetic techniques to evaluate the members of a large kindred. Twenty surviving and 24 deceased family members had hypertrophic cardiomyopathy; 58 surviving members were unaffected. Genetic-linkage analyses were performed with polymorphic DNA loci dispersed through...